All our 72mg/ml nicotine is provided for sale on a Business to Business (B2B) basis. It is provided to other businesses for:-
(a) the use in manufacturing products that fully comply with "The Tobacco and Related Product Regulations 2016"
(b) the use in manufacture of other products that are exempt from the scope of "The Tobacco and Related Product Regulations 2016"
Nicotine is a potent parasympathomimetic alkaloid found in the nightshade family of plants (solanaceae) and is a stimulant drug.
- Nicotine is a nicotinic acetylcholine receptor (nAChR) agonist, except at nAChRα9 and nAChRα10 where it acts as an antagonist. It is found in the leaves of Nicotiana rustica in amounts of 2–14%, the tobacco plant Nicotiana tabacum, Duboisia hopwoodii and Asclepias syriaca.
- It constitutes approximately 0.6–3.0% of the dry weight of tobacco and is present in the range of 2–7 µg/kg of various edible plants.
- It functions as an anti herbivore chemical; consequently, nicotine was widely used as an insecticide in the past and neonicotinoids such as imidacloprid are currently widely used.Nicotine is highly addictive.
- Around about 2 mg of absorbed nicotine, and in lesser doses of that order, the substance acts as a stimulant in mammals, while high amounts (50–100 mg) can be harmful. This stimulant effect is a contributing factor to the addictive properties.
Nicotine's addictive nature includes psychoactive effects, drug-reinforced behavior, compulsive use, relapse after abstinence, physical dependence and tolerance.
The health effects of long-term nicotine use is unknown.
The general medical position is that nicotine itself poses few health risks, except among certain vulnerable groups.
- Nicotine is increasingly used as a tool to quitting smoking has a good safety history to date.
- There is inadequate research to show that nicotine is associated with cancer in humans.
- It has been generally accepted that Nicotine in the form of nicotine replacement products is less of a cancer risk than smoking.
- Nicotine is linked to possible birth defects, During pregnancy, there are risks to the child later in life for type 2 diabetes, obesity, hypertension, neurobehavioral defects, respiratory dysfunction, and infertility.
- At high-enough doses nicotine is potentially lethal, and at high-enough doses it is associated with poisonings.